During the winter of 1820 -21, the first religious services were believed to be held in the school. A log courthouse, the first of three, was built in 1825 and by 1834 there were about sixty buildings and a population of nearly 300 persons. In 1833, Millersburg contained ten stores, four taverns, four practicing physicians, three attorneys, one printing office, one meeting house, one apothecary's shop, and 73 dwelling houses
Millersburg was incorporated February 17, 1835.